254. Altered Structural Covariance Network Patterns in Young Adults With High Polygenic Risk for Premature Brain Aging

Structural covariance networks (SCN) in the brain undergo characteristic changes across the lifespan, with local segregation network properties such as modularity decreasing through adolescence. Variants of age-dependent genes leading to accelerated molecular brain aging may affect typical SCN trajectories. Here, we set out to evaluate the SCN effects of a novel polygenic risk score (PRS-AGE) indexing vulnerability to faster molecular brain aging in young adults.