Distinct Pattern of Synaptic Loss in Parkinson's Disease Depression

Yanghong Yang,Mika Naganawa,Praveen Honhar,Sule Tinaz,Mark Dias,Shannan Henry,Jim Ropcham,Robert Comley,Nabeel Nabulsi,Yiyun Huang,Richard Carson,Sjoerd Finnema,David Matuskey,Sophie Holmes

Biological Psychiatry（2023）

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摘要

Depression is the most common psychiatric condition seen in PD. Using PET and [11C]UCB-J – a marker for synaptic density, we have previously provided in-vivo evidence for disease-specific synaptic loss in both major depressive disorder (MDD) and Parkinson’s disease (PD). No study to date has investigated synaptic loss in PD with MDD.

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关键词

synaptic loss,parkinsons disease,depression

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