336. Longitudinal Associations Between Amygdala-Medial Prefrontal Cortex Connectivity and Depression Symptoms in Brazilian Adolescents

Research suggests that individuals with depression evidence altered brain function within the emotion regulation network. Functional magnetic resonance imaging (fMRI) studies have also found that heightened threat-related amygdala activity and altered amygdala-prefrontal cortex connectivity are associated with adolescent depression by way of dysregulated emotional reactivity and regulation. However, the majority of neurobiology research has been conducted in high-income countries and with cross-sectional study designs, leaving a gap in research on youth in low-or-middle income countries. The present study examines longitudinal associations between emotion-related brain function and depression symptoms in adolescents from Brazil, a middle-income country (MIC).