279. Circadian Rhythms in Striatal-Like Neurons Generated from Bipolar Disorder Patients

Bipolar disorder (BD) is a serious mental illness characterized by recurrent episodes of depression and mania and disrupted circadian rhythms. BD patients show alterations in reward processing in the striatum, which is predominately composed of medium spiny neurons (MSNs) that express dopamine receptors. Therefore, MSNs are critically important for motivated behavior and are the targets of antipsychotic drugs. However, to date, induced pluripotent stem cell (iPSC) models of BD have focused on glutamatergic neurons.