210. Feasibility and Reliability of a Combined Virtual Reality - Electroencephalogram Paradigm to Assess Sensory Information Processing in Schizophrenia Patients

Electroencephalogram (EEG)-based measures of early auditory information processing (EAIP), utilize isolated sound fragments (tones, clicks), presented in an artificial context of a laboratory setting. We developed and tested two virtual reality (VR)-based EEG paradigms to measure EAIP evoked by naturalistic sound stimuli (e.g., footsteps, jackhammer) presented in familiar VR-delivered contexts (e.g., walking down the street, walking past a construction site) and assessed the sensitivity of these VR-based measures to identify EAIP deficits in schizophrenia patients (SZ) compared to healthy controls (HC).