449. Evidence of Hyperplasticity in the Left Dorsolateral Prefrontal Cortex in Autistic Adults: Preliminary Results

An excessive long-term potentiation (LTP) or hyperplasticity was found in the motor cortex in autistic adults using transcranial magnetic stimulation. Whether dorsolateral prefrontal cortex (DLPFC), which is involved in higher-order processes, has atypical LTP in autism, is unknown. Using the combination of paired associative stimulation (PAS) and electroencephalography (EEG) (PAS-EEG), we assessed LTP in the left DLPFC in autistic adults and explored correlation between LTP and resting-state functional magnetic resonance imaging (fMRI) functional connectivity (FC) patterns. We anticipated that, compared to neurotypical (NT) controls, autistic adults will display hyperplasticity in the left DLPFC.