Clinical significance of FOXP3 mRNA expression in patients with B chronic lymphocytic leukemia: A preliminary study.

Chronic lymphocytic leukemia (CLL) is due accumulation of monoclonal B- cell lymphocytes in different organs in the body as the bone marrow. There is a positive relationship between T regs cells and the occurrence of CLL. The main objective of this study was to investigate the role of FOXP3 expression in peripheral blood in B- cell of CLL. This cross-sectional descriptive study included 30 newly diagnosed chronic lymphocytic patients and 30 normal controls. FOXP3 gene expression was assessed. CLL patients showed higher FOXP3 gene expression as compared to that identified in normal controls (3.5 ± 1.5 and 1 ± 0.5, respectively). In conclusion, FOXP3 gene expression was higher in CLL patients when compared with normal controls. The indication of such finding is discussed in this report.