Dysregulated pancreatic lipid phenotype, inflammation and cellular injury in a chronic ethanol feeding model of hepatic alcohol dehydrogenase-deficient deer mice.

Mukund P Srinivasan,Kamlesh K Bhopale,Anna A Caracheo,Lata Kaphalia,Vsevolod L Popov,Paul J Boor,Bhupendra S Kaphalia

Life sciences（2023）

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摘要

These findings suggest that the liver-pancreatic axis plays a crucial role in etiopathogenesis of ACP, as the increased body burden of EtOH due to hepatic ADH deficiency exacerbates pancreatic injury.

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关键词

AMPKα signaling,Alcoholic chronic pancreatitis,Deer mice,Fatty acid ethyl esters,Lipid metabolism,Pancreatic interstitial fatty inflammation

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