Optimization of Physicochemical Properties of Pyrrolidine GPR40 AgoPAMs Results in a Differentiated Profile with Improved Pharmacokinetics and Reduced Off-Target Activities.
BIOORGANIC & MEDICINAL CHEMISTRY（2023）
Key words
GPR40,FFAR1,GLP-1,Type 2 diabetes,AgoPAM,Pyrrolidine,Hyperglycemia,Saturation,Chirality,Polarity
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