Toll-like receptor 7 agonist, GS-986, is an immune-stimulant inducing follicular helper T cells and expanding HBs antigen-specific B cells in vitro.

Taizo Mori,Sachiyo Yoshio,Shiori Yoshikawa,Yuriko Tsustui,Toshihiro Sakata,Yuichi Yoshida,Yuzuru Sakamoto,Hironari Kawai,Yosuke Osawa,Taiji Yamazoe,Yoshihiko Aoki,Simon P Fletcher,Tatsuya Kanto

Liver international : official journal of the International Association for the Study of the Liver（2023）

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摘要

GS-986 is an adjuvant that stimulates pDCs to induce Tfh differentiation and antigen-specific B-cell production. This immune profile may be beneficial for therapeutic application as an immune modulator in CHB patients.

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关键词

HBV,HBs antibody,TLR7 agonists,follicular helper T cells,plasmacytoid dendritic cell

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