Highly Regioselective Synthesis of N--trifluoromethyl 2-pyridones via anti-Markovnikov Hydroamination of -(trifluoromethyl)styrenes with 2-pyridones

Yi Zhang,Zhudi Sun,Jingjing He,Yupian Deng, Ying Liu,Pai Zheng,Song Cao

Chemistry, an Asian journal（2023）

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摘要

A novel and facile method for the synthesis of N-beta-CF3-substituted 2-pyridones via hydroamination of alpha-(trifluoromethyl)styrenes with 2-pyridones was described. The reaction proceeded smoothly at room temperature, affording a variety of N-(beta-trifluoromethyl-beta-arylethyl)pyridin-2(1H)-ones in moderate to good yields with excellent N-regioselectivity.

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关键词

2-pyridones,N-β-trifluoromethyl 2-pyridones,hydroamination,regioselectivity,α-(trifluoromethyl)styrenes

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