Evolution of Plasmodium falciparum antimalarial drug resistance markers post-adoption of artemisinin-based combination therapies in Yaounde, Cameroon.

Peter Thelma Ngwa Niba,Akindeh Mbuh Nji,Jean Paul Kengne Chedjou,Helle Hansson,Emma Filtenborg Hocke,Innocent Mbulli Ali,Olivia Achonduh-Atijegbe,Marie-Solange B Evehe, Marie Helene Munck Jørgensen,Calvino Tah Fomboh,Liwang Cui,Gillian Stresman,Jude D Bigoga,Michael Alifrangis,Wilfred F Mbacham

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases（2023）

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摘要

This study documented a near complete reversion to sensitive parasites for markers conferring resistance to the 4-aminoquinolines and arylamino alcohols in Yaounde. Contrariwise, the Pfdhfr mutations associated with pyrimethamine resistance are moving towards saturation.

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关键词

Cameroon,Plasmodium falciparum,artemisinin-based combination therapies,drug resistance,evolution,targeted amplicon deep sequencing

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