High baseline tumor burden‐associated macrophages promote an immunosuppressive microenvironment and reduce the efficacy of immune checkpoint inhibitors through the IGFBP2‐STAT3‐PD‐L1 pathway
Cancer Communications（2023）
Abstract
This study suggested that the low efficacy of ICI treatment in HTB tumors is mainly attributed to the intratumoral accumulation of PD-L1 M2-like macrophages via the IGFBP2-STAT3-PD-L1 signaling pathway and their substantial inhibitory effects on T cell proliferation and activation.
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Key words
CD8+ T cell,IGFBP2,PD-L1,STAT3,immune checkpoint inhibitor,macrophage,tumor burden,tumor immune microenvironment
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