Quantification of myocardial blood flow using dynamic myocardial CT perfusion compared with 82Rb PET

TOC summary: Myocardial blood flow (MBF) obtained with dynamic myocardial CT perfusion is underestimated when compared with reference standards. This is partially explained by incomplete extraction of iodinated contrast to the myocardial tissue. We aimed to establish an extraction function for iodinated contrast in healthy individuals without coronary artery disease, use the function to calculate MBF and to compare this with MBF measured with 82Rb positron emission tomography. We found that flow estimates obtained with dynamic myocardial CT perfusion during stress were, after conversion to MBF using the extraction of iodinated contrast, correlated with absolute MBF quantified with 82Rb positron emission tomography.