Mechanisms of inhibition of human monoclonal antibodies in immune thrombotic thrombocytopenic purpura

Konstantine Halkidis,Chan Meng,Szumam Liu,Leland Mayne,Don L. Siegel,X. Long Zheng

BLOOD（2023）

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摘要

•Molecular mechanism underlying autoantibody-mediated inhibition of ADAMTS13 activity in iTTP is not fully understood.•We found that binding of human antispacer antibody to ADAMTS13 results in conformational changes in its catalytic domain.

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human monoclonal antibodies

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