Modulation mechanism of aquaporins by mercury revealed by solid-state NMR and molecular dynamics simulations
MAGNETIC RESONANCE LETTERS(2023)
Abstract
In a recent paper,the structural basis of mercury-mediated changes in aquaporins'(AQPs)function has been revealed at the atomic level by solid-state nuclear magnetic resonance(ssNMR)spectroscopy and molecular dynamics(MD)simulations[1].This work has demonstrated an interesting case of metal ion-protein interaction.It provided valuable insights on how mercury ions achieve opposite regulations of AQP permeability by disrupting the hydrogen bonding network around arginine residues().
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Key words
aquaporins,molecular dynamics,mercury,solid-state
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