Role of HNF4alpha-cMyc interaction in liver regeneration and recovery after acetaminophen-induced acute liver injury.

Manasi Kotulkar,Diego Paine-Cabrera,Sarah Abernathy,Dakota R Robarts,Wendena S Parkes,Kristi Lin-Rahardja,September Numata,Margitta Lebofsky,Hartmut Jaeschke,Udayan Apte

Hepatology (Baltimore, Md.)（2023）

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摘要

These data show that HNF4α interacts with Nrf2 and promotes GSH replenishment aiding in recovery from APAP-induced liver injury, a process inhibited by cMyc. These studies indicate that maintaining HNF4α function is critical for regeneration and recovery after APAP overdose.

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