Mechano-Redox Control of Macrophage-1 Antigen De-Adhesion From ICAM-1 (Intercellular Adhesion Molecule 1) by Protein Disulfide Isomerase Promotes Directional Movement Under Flow.

Alexander Dupuy, Camilo Aponte Santamaría,Adva Yeheskel,Elinor Hortle,Stefan H Oehlers,Frauke Gräter,Philip J Hogg,Freda H Passam,Joyce Chiu

Circulation research（2023）

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摘要

Shear-dependent PDI cleavage of the neutrophil Mac-1 C224-C264 disulfide bond triggers Mac-1 de-adherence from ICAM-1 at the trailing edge of the cell and enables directional movement of neutrophils during inflammation.

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关键词

cell migration,disulfides,integrin,neutrophils,shear force

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