Alternative routes for tranexamic acid treatment in obstetric bleeding (WOMAN-PharmacoTXA trial): a randomised trial and pharmacological study in caesarean section births.
BJOG : an international journal of obstetrics and gynaecology（2023）
摘要
Both IM and oral TXA are well tolerated. Oral TXA took about 1 hour to reach minimum therapeutic concentrations and would not be suitable for emergency treatment. Intramuscular TXA inhibits fibrinolysis within 10 minutes and may be a suitable alternative to IV.
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关键词
caesarean section,clinical trial,intramuscular,oral,pharmacodynamics,pharmacokinetics,postpartum haemorrhage,tranexamic acid
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