Creation of single molecular conjugates of metal-organic cages and DNA.

Toshinobu Nakajo,Shinpei Kusaka,Haruka Hiraoka,Kohei Nomura, Noriaki Matsubara, Rintaro Baba,Yuki Yoshida,Kosuke Nakamoto,Masakazu Honma,Hiroaki Iguchi,Takayuki Uchihashi,Hiroshi Abe,Ryotaro Matsuda

CHEMICAL COMMUNICATIONS（2023）

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摘要

Here we report the development of an equimolar conjugate of a metal-organic cage (MOC) and DNA (MOC-DNA). Several MOC-DNA conjugates were assembled into a programmed structure by coordinating with a template DNA having a complementary base sequence. Moreover, conjugation with the MOC drastically enhanced the permeability of DNA through the lipid bilayer, presenting great potential as a drug delivery system.

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关键词

metal–organic cages,single molecular conjugates,dna

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