Mn(acac)(3) as a Remarkably Efficient Oxidant: Mediation of the Radical Addition/Cyclization Cascade of Boronic Acids with Isocyanides

A remarkably efficient protocol for the mediation of Mn(III) to the radical addition/cyclization cascade of boronic acids with isocyanides leading to 3-aminoquinoline derivatives is established. A reasonable explanation to the high reactivity of the Mn(III) salt was suggested. Application of the synthetic method to the late-stage modification of drug molecules was also presented.