Effects of ABCB1, ABCC2, UGT2B7 and HNF4α genetic polymorphisms on oxcarbazepine concentrations and therapeutic efficacy in patients with epilepsy.
Seizure(2017)
摘要
•The effects of 4 SNPs on OXC level and response in patients with epilepsy were studied.•ABCB1 rs1045642 was related with normalized OXC concentration and responsiveness.•UGT2B7 rs7439366 polymorphism exhibited an association with OXC responsiveness.
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关键词
Oxcarbazepine,Pharmacogenetics,ABCB1,ABCC2,UGT2B7,HNF4α
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