A transient protein megacomplex that controls degradation of cell components

NATURE（2023）

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摘要

Whether to self-degrade is a crucial cellular decision. When nutrients are abundant, degradation of cell components is reduced through inactivation of a protein called TFEB by the enzyme complex mTORC1. The structure of a megacomplex consisting of 36 polypeptide chains, which presents TFEB to mTORC1, has been resolved.

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Structural biology,Cell biology

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