Development of affinity polymeric particles for the removal of 4-dimethy-laminopyridine (DMAP) from active pharmaceutical ingredient crude streams using a green technology
JOURNAL OF SUPERCRITICAL FLUIDS(2023)
摘要
Polymeric particles with affinity for 4-dimethylaminipyridine (DMAP) were developed by molecular imprinting using supercritical carbon dioxide (scCO2) technology, for cleanup of this potentially genotoxic impurity from crude mixtures of Active Pharmaceutical Ingredients (APIs). DMAP-molecularly imprinted polymer (DMAP-MIP) and the respective control, the non-molecularly imprinted polymer (NIP) were produced by free radical poly-merization using methacrylic acid as monomer, ethylene glycol dimethacrylate as crosslinker and AIBN as free-radical initiator in scCO2. The materials were obtained in high yield and were characterized chemically, phys-ically and morphologically. Their extraction efficiency was evaluated by dynamic binding experiments using two solutions: i) a solution containing 104 ppm DMAP solution; ii) model pharmaceutical mixture containing 104 ppm of DMAP and 1018 ppm of Mometasone furoate (API). Particles were able to remove 18.3 mu mol DMAP/g polymer from a 104 ppm DMAP solution (i) and 1004.6 mu mol DMAP/g API (ii). In addition, high recoveries of both DMAP and API were obtained, above 99%.
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关键词
Supercritical carbon dioxide,Genotoxin removal,Solid-phase extraction,Molecularly imprinted polymer,Affinity purification
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