Synthesis of alpha-Carbonyl-alpha '-amide Sulfoxonium Ylides from Isocyanates with Complete Atom Economy

An efficient catalyst-and additive-free facile syn-thesis of alpha-carbonyl-alpha '-amide sulfoxonium ylides from isocyanates and beta-ketosulfoxonium ylides with complete atom economy has been described. The beta-ketosulfoxonium ylides and isocyanates adorned with various functional groups were well-tolerated and afforded moderate to high yields of the alpha-carbonyl-alpha '-amide sulfoxonium ylide derivatives. Finally, using large-scale reactions and converting the synthesized ylides into other valuable compounds, we demonstrated the practicality of this synthetic method.