Rescue Medications for Acute Repetitive Seizures

Purpose of review This article reviews the current evidence-based treatments for the management of acute repetitive seizures (ARS). Recent findings Half of patients with refractory epilepsy will experience ARS, but rescue medications are underutilized. Benzodiazepines remain first-line treatment for the management of acute seizures. There are multiple approved medications, and ongoing studies investigating new routes of administration. Summary Clinicians must recognize patients at risk of acute repetitive seizures and be aware of available options for their treatment in the outpatient setting. Additional research is needed to identify which specific treatments are best for different types of patients.