Nodular Fasciitis False Positive on F-18-Piflufolastat and C-11-Choline PET/CT

PET/CT plays a crucial role in the management of prostate cancer with several emerging and established radiopharmaceuticals, including F-18-piflufolastat and C-11-choline. These radiotracers are thought to be relatively specific to prostate cancer; however, uptake has also been demonstrated in other benign and malignant lesions. Nodular fasciitis is a rapidly growing benign soft tissue neoplasm that is typically self-limiting. Although a few case reports describe Ga-68-PSMA uptake in nodular fasciitis, uptake of C-11-choline and other PSMA-targeted PET probes, including F-18-piflufolastat, have not previously been reported. We present a novel case of nodular fasciitis demonstrating both F-18-piflufolastat and C-11-choline avidity.