Synthesis of 2-Chloro-6-(trifluoromethyl)pyridine-3,5-dicarbonitrile: A Versatile Building Block for the Synthesis of Substituted Trifluoro Methyl Pyridine Derivatives

A simple and highly efficient (concise 3-step) synthesis of 2-chloro-6-(trifluoromethyl)pyridine-3,5-dicarbonitrile has been developed from readily available starting materials. Furthermore, the selective reactivity of this tetra- substituted pyridine with different carbon, sulfur, nitrogen and oxygen nucleophiles offers great scope for the synthesis of novel highly substituted pyridine derivatives in decent to good yields.