Elements-Continuous-Flow Platform for Coupling Reactions and Anti-viral Daclatasvir API Synthesis

A novel nanotextured Ni@Cu material embedded electromicroflow reactor with minimal electrode distance has been employed to synthesize biphenyls via the construction of a new C-C bond. The reported protocol is devoid of noble metals and involves co-reductant/oxidant-free conditions in a fast manner for the synthesis of substituted/unsubstituted biphenyl systems. The electro-reactor volume was optimized for gram-scale biphenyl synthesis and further extended for an integrated total process system reducing the tedious downstream process by selective removal of unwanted chemicals/solvent. The continuous microflow synthesis of daclatasvir has now been accomplished with a good yield.