The potential of Fermented Asparagus sprengeri extract by Lactobacillus plantarum DMS 20174 on Antioxidant Properties and Memory Retention in vitro and in vivo.

Asparagus sp. are a superior gift from nature to promote a disease-free, healthy lifestyle. Through Gut-Brain Axis contact, Lactobacillus strains perform a therapeutic role in neurodegenerative illnesses, particularly Alzheimer's disease (AD). This study was aimed to determine the effect of asparagus extract on Lactobacillus plantarum DMS 20174 (L. plantarum) resistance to acid, bile salt, gastric and intestinal environments. Also, the impact of fermented asparagus extract on antimicrobial, antioxidant and anti-cholinesterase activities was evaluated. Furthermore, the study aimed to investigate the dietary treatment effect of fermented Asparagus extract on anti-Alzheimer and microbiological properties in high fat diet (HFD) fed albino rats. L. plantarum cells gained some resistance towards harsh gastric and intestinal conditions with asparagus extract. Various short chain fatty acids (SCFA) were detected by HPLC in cell free extract (CFE) of the fermented extract. Its antimicrobial activity, scavenging of DPPH and anti-cholinesterase activity were improved. Treatment of high fat diet (HFD) groups with L. plantarum and asparagus extract decreased acetyl cholinesterase (AChE) and malondialdehyde (MDA). Furthermore, treatment with DMS 20174, asparagus extract, and the combined mixture had greater counts of Lactobacilli and lower counts of total aerobes, coliform bacteria, staphylococci, and fungi with HF-fed mice. In conclusions: fermented asparagus extract may be useful in reducing risk of neurodegenerative diseases.