Doxorubicin compositions with biocompatible terpolymer of N-vinylpyrrolidone, methacrylic acid and triethylene glycol dimethacrylate

Svetlana V. Kurmaz, Irina I. Ivanova,Nina S. Emelyanova,Dmitry V. Konev,Vladimir A. Kurmaz,Natalia V. Filatova,Anastasia A. Balakina,Alexei A. Terentiev

Mendeleev Communications（2023）

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摘要

Compositions of doxorubicin with a terpolymer of N-vinylpyrrolidone, methacrylic acid and triethylene glycol dimethacrylate have been prepared and investigated by UV-VIS and NMR spectroscopy, cyclic voltammetry and DFT quantum chemical modeling. Oxygen containing groups of the terpolymer and hydrogen atoms of the drug OH and NH3+ groups form hydrogen bonds. The compositions have lower cytotoxicity in vitro compared with that of free doxorubicin.

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关键词

biocompatible terpolymer,triethylene glycol,methacrylic acid,n-vinylpyrrolidone

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