Supplementary Fig. S1, S2, S3, S4, S5 and S6. from TRP53 Mutants Drive Neuroendocrine Lung Cancer Through Loss-of-Function Mechanisms with Gain-of-Function Effects on Chemotherapy Response

Fig. S1 presents mutant Trp53 protein expression in lung tumors and metastases. Fig. S2 shows PTEN expression in lung tumors and metastases. Fig. S3 presents mTOR pathway inhibition by rapamycin in primary tumor cell cultures. Fig. S4 shows establishment of chemoresistant and chemosensitive primary cell cultures. Fig. S5 presents chemotherapeutic response of primary tumor cells derived from chemoresistant and chemosensitive lung tumors. Fig. S6 presents the effect of cisplatin and etoposide on cell growth of lung tumors in vitro.