In vitro evaluation of photon and carbon ion radiotherapy in combination with cisplatin in head and neck squamous cell carcinoma cell lines.

Xumeng Fang,Pian Sun,Yuanli Dong,Yangle Huang,Jiade Jay Lu,Lin Kong

Frontiers in Oncology（2023）

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摘要

In conclusion, high linear energy transfer (LET) CIRT was more effective than photon irradiation to prevent the proliferation of HNSCC cell lines. Additional treatment with cisplatin could sensitize photon irradiation but showed no effect on carbon ion irradiation.

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关键词

carbon ion radiotherapy (CIRT),cisplatin,head and neck squamous cell carcinoma (HNSCC),radiosensitisation,relative biological effectiveness (RBE)

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