Novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-HT6 receptor interaction

Battistina Asproni,Marco Catto,Giovanni Loriga,Gabriele Murineddu,Paola Corona,Rosa Purgatorio,Elena Cichero,Paola Fossa, Naomi Scarano,Antón L. Martínez,José Brea,Gérard A. Pinna

Bioorganic & medicinal chemistry（2023）

引用 0|浏览0

暂无评分

摘要

•Synthesis of novel thienocycloalkylpyridazinones.•Biological evaluation: hAChE, hBChE enzyme inhibition; serotonin 5-HT6, 5-HT1A, 5-HT7 receptor interaction.•Molecular modeling studies.•In silico prediction of ADME properties.

查看译文

关键词

Acetylcholinesterase inhibitors,5-HT6 receptor ligands,Multitarget-directed ligands,Alzheimer’s disease,Thienocycloalkylpyridazinone derivatives

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要