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Irisin attenuates fine particulate matter induced acute lung injury by regulating Nod2/NF-κB signaling pathway

Rui Jiao,Zhuoxiao Han,Jiao Ma,Siyu Wu,Zheng Wang,Guangwei Zhou,Xinxiu Liu,Jing Li,Xixin Yan,Aihong Meng

Immunobiology（2023）

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Abstract
•After PM2.5 stimulation, the content of irisin in mouse lung tissue increased.•Irisin mitigated inflammatory changes in PM2.5-induced acute lung injury models.•Irisin inhibits NLRP3 inflammasome activation in MH-S cells.•Irisin may play an anti-inflammatory role through the Nod2/NF-κB signaling pathway.
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Key words
Acute lung injury,Inflammation,Irisin,NF-κB,Nod2,PM2.5
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