Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder

Dilansu Guneykaya,Bilge Ugursu,Francesca Logiacco,Oliver Popp,Maria Almut Feiks,Niklas Meyer,Stefan Wendt,Marcus Semtner, Fatma Cherif,Christian Gauthier,Charlotte Madore,Zhuoran Yin, Özcan Çınar,Taner Arslan, Zoltan Gerevich,Philipp Mertins,Oleg Butovsky,Helmut Kettenmann,Susanne A. Wolf

Brain, Behavior, and Immunity（2023）

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摘要

•Microglia structure, function, and proteome profile is altered mainly in NLGN4-/- male mice.•P2YR12-dependent microglial signaling is altered only in NL4GN-/- male mice.•The NL4GN mutation alters gamma oscillations in a sex-specific manner.•Estrogen treatment restored P2YR12 signaling in NL4GN-/- male mice.

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