Supplementary Figure S6 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress

Takatsune Shimizu,Eiji Sugihara, Sayaka Yamaguchi-Iwai,Sakura Tamaki, Yuko Koyama, Walied Kamel,Arisa Ueki,Tomoki Ishikawa,Tatsuyuki Chiyoda,Satoru Osuka,Nobuyuki Onishi,Hiroko Ikeda,Junzo Kamei,Koichi Matsuo,Yumi Fukuchi,Toshihiro Nagai,Junya Toguchida,Yoshiaki Toyama,Akihiro Muto,Hideyuki Saya

crossref（2023）

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摘要

Supplementary Figure S6: (A) Serum concentrations of Asp, Gln, and Glu in mice. (B) H&E staining of representative AXT cell-derived tumors from mice treated with chemotherapy plus L-asparaginase or bafilomycin A as in Figure 6A. (C) Proposed model for the role of IGF- or insulin-mediated dormancy in osteosarcoma cells.

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