Supplementary Figure 2 from PP2A-B55β Antagonizes Cyclin E1 Proteolysis and Promotes Its Dysregulation in Cancer

PDF file - 167KB, Transfection of MDA-MB-231 cells with three different B55beta siRNAs decreases cyclin E1 protein level. Cells were harvested 48 hrs post-transfection. All subsequent experiments were performed using B55beta-siRNA-2. qPCR data showing efficiency of B55beta knockdown and potential effects on cyclin E1 expression are shown below. Expression was normalized to control (scrambled) siRNA.