Supplemental Figures S1-S9 from Grapefruit-Derived Nanovectors Use an Activated Leukocyte Trafficking Pathway to Deliver Therapeutic Agents to Inflammatory Tumor Sites

Supplemental Figures S1-S9. Chemokine receptors expressed on PMA stimulated EL4 cells (S1); Uptake of GNVs membrane derived vesicles and stability of IGNVs (S2); Transmigration of GNVs and IGNVs (S3); Expression of integrins on EL4 cells and LFA-1 on IGNVs (S4); Purification of plasma membrane from leukocytes and chemokines in the culture medium of human SW620 cells (S5); Effects of IGNVs on cell proliferation in vitro and potential toxicity in vivo (S6); Therapeutic drug-loaded IGNVs and Characterization of DOX-NPTM and control liposomes from Avanti (S7); Biodistribution of DOX in 4T1 tumor tissues and therapeutic effect of IGNV-Cur on the inhibition of DSS-induced mouse colitis (S8); Determination of critical GNV miceller concentration (S9).