Supplementary Figures 1-10 from LRP1B Deletion in High-Grade Serous Ovarian Cancers Is Associated with Acquired Chemotherapy Resistance to Liposomal Doxorubicin

PDF file - 1.8MB, Supp Fig S1. Variation in DNA copy number and gene expression among primary ovarian tumors and associated abdominal deposits Supp Fig S2. Heatmap of CNC in paired primary - relapse tumors for oncogenes/tumour suppressors and literature derived candidates Supp Fig S3. Box plots of gene expression changes of 19 literature derived candidates associated with resistance in ovarian cancer Supp Fig S4. Copy number genome in line view of primary sensitive tumor - relapse resistant ascites pairs Supp Fig S5. Genome in line view of primary resistant tumor - relapse resistant ascites pairs Supp Fig S6. Genome in line view of primary tumor - primary ascites samples Supp Fig S7. Schematic of reported mutations in LRP1B Supp Fig S8. LRP1B expression in 32 ovarian cancer and normal cell lines Supp Fig S9. LRP1B siRNA and minigene sequence targets Supp Fig S10. siRNA knockdown of LRP1B in vitro using individual siRNA constructs alters drug sensitivity in ovarian cancer cell lines, Kuramochi and JHOS3