Supplementary Tables 1 - 7 from Discrepancies in Cancer Genomic Sequencing Highlight Opportunities for Driver Mutation Discovery

Supplementary Table 1A. Mutations that were only identified by CCLE in the comparison of sequencing data of 1630 genes across 568 cell lines from CCLE and COSMIC . Supplementary Table 1B. Mutations that were only identified by COSMIC in the comparison of sequencing data of 1630 genes across 568 cell lines from CCLE and COSMIC. Supplementary Table 2. Sequencing cold spots (larger than 100bp) in cancer consensus and kinase genes identified from sequencing data of 10 CCLE whole exome sequencing files (not hybrid capture). Supplementary Table 3. New mutations detected by CRUK Manchester Institute sequencing that were not reported by either CCLE or COSMIC. Supplementary Table 4. Proportion of missense mutations exclusively reported by one institute (CCLE or COSMIC) that were subsequently found by CRUK MI sequencing. Supplementary Table 5. Sequencing statistics for CRUK MI sequencing. Supplementary Table 6. List of kinase and Cancer Census genes that were analyzed to identify sequencing cold-spots in 10 CCLE whole exome sequencing files Supplementary Table 7 Read coverage in CCLE Hybrid Capture data at the midpoint of the 20 largest cold-spots identified in CCLE from 10 lung whole exome sequencing files (not hybrid capture).