Supplementary Figures 1-5, Tables 1-5 from A Single-Nucleotide Substitution Mutator Phenotype Revealed by Exome Sequencing of Human Colon Adenomas

PDF file - 2600K, Supplementary Figure S1. Statistical analysis for calling single nucleotide substitutions (SNSs). Supplementary Figure S2. Example of LOH affecting the APC gene in a tubulovillous adenoma (TVA) with moderate dysplasia (polyp MS1). Supplementary Figure S3. LOH and copy number alterations (CNAs) for all polyps. The data are shown using circos plots. Supplementary Figure S4. Amplification of the MYC locus in an adenoma with severe dysplasia. Supplementary Figure S5. Calculation of mutation rates in normal colon tissue and adenomas. Supplementary Table S1. Clinical, histopathological and sequence coverage data for the examined polyps. Supplementary Table S2. Statistical analysis of cancer-driver genes. Supplementary Table S4. Coding lengths of 19,075 protein-coding genes distributed in 8 bins according to gene size. Supplementary Table S5. Genomic lengths of 19,075 protein-coding genes distributed in 8 bins according to gene size