Supplementary Figure 4 from Activation of the FGFR–STAT3 Pathway in Breast Cancer Cells Induces a Hyaluronan-Rich Microenvironment That Licenses Tumor Formation

PDF file - 116K, Supplemental Figure 4. Activation of FGFR (1) leads to increased gene expression and secretion of IL-6 family members (2). These bind to the gp130 receptor (3) which activates STAT3 (4). Phosphorylated STAT3 regulates HAS2 expression (5). HAS2 stimulates production of hyaluronan (6), which is then secreted and contributes to induced proliferation, migration and chemoresistance.