Supplemental Materials and Methods, Figure Legend, Figures S1-6 from SCCA1/SERPINB3 Promotes Oncogenesis and Epithelial–Mesenchymal Transition via the Unfolded Protein Response and IL6 Signaling

Supplemental Materials and Methods, Figure Legend, Figures S1-6. Figure S1. SCCA1-expressing MCF10A cells become independent of the hormonal factors. Figure S2. Expression of SCCA1 leads to IL-6 production. Figure S3. The induction of UPR by SCCA1 is dependent on its protease inhibition function. Figure S4. Silencing of ATF6a and PERK leads to decreased IL-6 production and cell proliferation in MDA-MB-231 cells. Figure S5. Silencing of SCCA results in decreased UPR, IL-6 production, and cell growth. Figure S6. Elevated SCCA1 expression leads to UPR and IL-6 production in various cell lines.