The small molecule ACM-001 improves cardiac function in a rat model of severe cancer cachexia.

Mareike S Poetsch,Sandra Palus,Sophie Van Linthout,Stephan von Haehling,Wolfram Doehner,Andrew J S Coats,Stefan D Anker,Jochen Springer

European journal of heart failure（2023）

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摘要

This study shows that 3 mg/kg/day ACM-001 restores the anabolic/catabolic balance in cardiac muscle leading to improved function. Moreover, not all beta-blockers have similar effects.

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关键词

Beta-blocker,Cancer cachexia,Cardiac wasting,Cardio-oncology,Cardiomyopathy,S-pindolol

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