Investigating the change in gene expression profile of blood mononuclear cells post-laparoscopic sleeve gastrectomy in Chinese obese patients.

Na Liu,Xiaolei Chen,Jianghua Ran,Jianhui Yin, Lijun Zhang,Yuelin Yang, Jianchang Cen, Hongmei Dai,Jiali Zhou, Kui Gao, Jihong Zhang,Liyin Liu,Zhiyuan Chen, Haibin Wang

Frontiers in endocrinology（2023）

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Abstract

This study identified three critical regulatory genes significantly differentiated between patients before and after LSG treatment and highlighted their potentially crucial role after bariatric surgery. This provides novel insights to increase our understanding of the underlying mechanisms of weight loss and associated metabolic improvement after bariatric surgery.

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Key words

bioinformatics,high-throughput sequencing,laparoscopic sleeve gastrectomy (LSG),leptin,obesity

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