Oncostatin M and Nivolumab Affect the Cytotoxic T-Cell Proportions and the Susceptibility to TRAIL-Induced Death in Non-Leukocyte Cell Subpopulations in Soft Tissue Sarcomas.

Giulia Toffanin,Andrej Ozaniak,Robin Bartolini,Martin Komarc,Rene Novysedlak,Michal Rataj,Jitka Smetanova,Antonio Rosato,Robert Lischke,Jirina Bartunkova,Zuzana Strizova

Pharmacology（2023）

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Abstract

In conclusion, the biological efficacy of OSM is reflected in the tumor microenvironment rather than in the peripheral blood of the patients in our cohort, and nivolumab could potentiate its mechanism of action in selected cases. Nevertheless, more histotype-tailored studies are needed to fully understand the functions of OSM in STSs.

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Key words

Cytokines,Monoclonal antibody,Nivolumab,Oncostatin M,Soft tissue sarcomas,T cells,Tumor microenvironment

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