Distinct gene dysregulation patterns herald precision medicine potentiality in systemic lupus erythematosus

•SLE transcripts defined 3 distinct clusters: interferon, inflammation, lymphocyte signaling.•Interferon gene upregulation denoted hematological activity and vasculitis.•Rs7918733 T > C was associated with upregulation of CASP7 in SLE patients.•Druggability analysis suggested CTSL activity depression through proteasome inhibition.