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Increased Metallothionein-1 Associated with Gout Activity and Tophi.

Yanmei Ma,Zhihua Yin,Hanying Dai,Dandan Wu,Junxiao Cong,Xinmin Huang,Xinpeng Chen,Linghua Zou,Zhizhong Ye,Zhong Huang

Immunological investigations（2023）

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Abstract
The higher levels of MT-1 were found in patients with gout, which were correlated with disease activity and gout related pro-inflammatory cytokines. Indicating MT-1 may serve as a new marker for predicting disease activity.: IL-1β: Interleukin 1β; MT-1: Metallothionein-1; CRP: C-Reactive Protein; ROS: Reactive Oxygen Species; IL-10: Interleukin 10; TGF-β: Transforming Growth Factor Beta.
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Key words
Gout,metallothionein-1,peripheral blood mononuclear cell,tophi
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