Supplementary Materials and Methods, Supplementary Tables 1 and 2, and Supplementary Figures 1 through 3 from Deguelin Analogue SH-1242 Inhibits Hsp90 Activity and Exerts Potent Anticancer Efficacy with Limited Neurotoxicity

Supplementary Materials and Methods. Supplementary Table 1. The acquisition of drug resistance in several drug resistant cells (designated '/R') upon corresponding anticancer drug treatment. Supplementary Table 2. Docking and scoring known Hsp90 inhibitors into the C-terminal ATP binding pocket of Hsp90. Supplementary Figure 1. Chemical structure of SH-1242. Supplementary Figure 2. Inhibitory effect of SH-1242 on the viability of a panel of human lung cancer cells with or without anticancer drug resistance. Supplementary Figure 3. Minimal involvement of ROS in the regulation of Akt phosphorylation and apoptosis induction mediated by SH-1242 treatment.